The recent COVID-19 pandemic has led to a drastic increase in the frequency of videoconferencing used for work, school, and socialization. To date, the user experience impact of this increased screen time is unknown. We surveyed 489 participants (Mage¼24.19, Range ¼ 18–72) to determine which factors best predict visual and body discomfort. Along with gender, screen time, and level of subjective meeting fatigue, meeting duration significantly predicted visual discomfort. In contrast, meeting frequency (along with the level of meeting engagement, subjective meeting fatigue, and other covariates) significantly predicted bodily discomfort. These results highlight the need for greater ergonomic evaluation of work-from-home setups, as well as point to a need for shorter, fewer, and more engaging video meetings for the average worker from home.